Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling
A Balistrieri, A Makino, JXJ Yuan - Physiological reviews, 2023 - journals.physiology.org
The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …
[HTML][HTML] The role of endothelial cells in pulmonary hypertension: old concepts and new science
M Haensel, B Wojciak-Stothard - Current Opinion in Physiology, 2023 - Elsevier
Endothelial dysfunction plays a key role in the initiation and progression of pulmonary
hypertension (PH), a fatal and currently incurable disease associated with increased …
hypertension (PH), a fatal and currently incurable disease associated with increased …
Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-κB/HIF-1α/Twist1 pathway
EL Wang, JJ Zhang, FM Luo, MY Fu, D Li, J Peng, B Liu - Life Sciences, 2023 - Elsevier
Abstract Aims Endothelial-mesenchymal transition (EndMT) is one of the critical factors
leading to vascular remodeling in pulmonary hypertension (PH). Recent studies found that …
leading to vascular remodeling in pulmonary hypertension (PH). Recent studies found that …
LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension
J Steppan, H Wang, K Nandakumar… - … of Physiology-Lung …, 2024 - journals.physiology.org
Background: Conduit pulmonary arterial stiffening and the resultant increase in pulmonary
vascular impedance has emerged as an important underlying driver of pulmonary arterial …
vascular impedance has emerged as an important underlying driver of pulmonary arterial …
[HTML][HTML] Differential expression spectrum and targeted gene prediction of tRNA-derived small RNAs in idiopathic pulmonary arterial hypertension
Y Chen, Y Tang, S Hou, J Luo, J Chen, H Qiu… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Idiopathic pulmonary arterial hypertension (PAH) is a potentially fatal
pulmonary vascular disease with an extremely poor natural course. The limitations of current …
pulmonary vascular disease with an extremely poor natural course. The limitations of current …
Pulmonary artery smooth muscle cell pyroptosis promotes the proliferation of PASMCs by paracrine IL‑1β and IL‑18 in monocrotaline‑induced pulmonary arterial …
QY Zhou, W Liu, SX Gong, Y Tian… - Experimental and …, 2024 - spandidos-publications.com
Pulmonary arterial hypertension (PAH) is a common vascular disease, and pulmonary
vascular remodeling is a pivotal pathophysiological mechanism of PAH. Major pathological …
vascular remodeling is a pivotal pathophysiological mechanism of PAH. Major pathological …
A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells
S Niedermeyer, X Yun, M Trujillo… - … of Physiology-Lung …, 2024 - journals.physiology.org
Pulmonary hypertension (PH) is a condition in which remodeling of the pulmonary
vasculature leads to hypertrophy of the muscular vascular wall and extension of muscle into …
vasculature leads to hypertrophy of the muscular vascular wall and extension of muscle into …
Aquaporin 1 confers apoptosis resistance in pulmonary arterial smooth muscle cells from the SU5416 hypoxia rat model
X Yun, S Niedermeyer, MR Andrade… - Physiological …, 2024 - Wiley Online Library
Pulmonary hypertension (PH) arises from increased pulmonary vascular resistance due to
contraction and remodeling of the pulmonary arteries. The structural changes include …
contraction and remodeling of the pulmonary arteries. The structural changes include …
A cluster of heritable pulmonary arterial hypertension cases in a family with all three siblings carrying the same novel AQP1 c.273C>G variant‐a case report
KW Liang, SK Chang, YW Chen, WJ Tsai… - Pulmonary …, 2023 - Wiley Online Library
Abstract Approximately 25%–30% of patients diagnosed with idiopathic pulmonary arterial
hypertension (PAH) have a clustered underlying Mendelian genetic cause and should be …
hypertension (PAH) have a clustered underlying Mendelian genetic cause and should be …
Aqp5−/− mice exhibit reduced maximal body O2 consumption under cold exposure, normal pulmonary gas exchange, and impaired formation of brown adipose …
S Al-Samir, AÖ Yildirim, VK Sidhaye… - American Journal …, 2023 - journals.physiology.org
The fundamental body functions that determine maximal O2 uptake (V̇o2max) have not
been studied in Aqp5−/− mice (aquaporin 5, AQP5). We measured V̇o2max to globally …
been studied in Aqp5−/− mice (aquaporin 5, AQP5). We measured V̇o2max to globally …