The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine

S Pan, A Ding, Y Li, Y Sun, Y Zhan, Z Ye… - Chemical Society …, 2023 - pubs.rsc.org
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

μMap-Red: proximity labeling by red light photocatalysis

BF Buksh, SD Knutson, JV Oakley… - Journal of the …, 2022 - ACS Publications
Modern proximity labeling techniques have enabled significant advances in understanding
biomolecular interactions. However, current tools primarily utilize activation modes that are …

Recent progress and challenges of photocatalytic CO2 conversion into value-added multi-carbon products

C Li, J Wang, L Tong, Y Wang, P Zhang, M Zhu… - Coordination Chemistry …, 2024 - Elsevier
In recently years, photocatalytic CO 2 conversion into the value-added chemicals represents
a promising approach to relieve the current energy and environmental problems, because it …

Improved transition metal photosensitizers to drive advances in photocatalysis

D Kim, VQ Dang, TS Teets - Chemical Science, 2024 - pubs.rsc.org
To function effectively in a photocatalytic application, a photosensitizer's light absorption,
excited-state lifetime, and redox potentials, both in the ground state and excited state, are …

Orange Light-Driven C(sp2)–C(sp3) Cross-Coupling via Spin-Forbidden Ir(III) Metallaphotoredox Catalysis

KA Xie, E Bednarova, CL Joe, C Lin… - Journal of the …, 2023 - ACS Publications
We report the development and characterization of a library of Ir (III) photocatalysts capable
of undergoing spin-forbidden excitation (SFE) under orange light irradiation (595 nm). These …

A genetically encoded photoproximity labeling approach for mapping protein territories

N Hananya, X Ye, S Koren… - Proceedings of the …, 2023 - National Acad Sciences
Studying dynamic biological processes requires approaches compatible with the lifetimes of
the biochemical transactions under investigation, which can be very short. We describe a …

Switchable DNA Catalysts for Proximity Labeling at Sites of Protein–Protein Interactions

AN Ogorek, X Zhou, JD Martell - Journal of the American Chemical …, 2023 - ACS Publications
Proximity labeling (PL) has emerged as a powerful approach to elucidate proteomes within
a defined radius around a protein of interest (POI). In PL, a catalyst is attached to the POI …

Photocatalytic Activation of Aryl (trifluoromethyl) Diazos to Carbenes for High-Resolution Protein Labeling with Red Light

DC Cabanero, SK Kariofillis, AC Johns… - Journal of the …, 2024 - ACS Publications
State-of-the-art methods in photoproximity labeling center on the targeted generation and
capture of short-lived reactive intermediates to provide a snapshot of local protein …

Ligand-directed photocatalysts and far-red light enable catalytic bioorthogonal uncaging inside live cells

JE Rosenberger, Y Xie, Y Fang, X Lyu… - Journal of the …, 2023 - ACS Publications
Described are ligand-directed catalysts for live-cell, photocatalytic activation of
bioorthogonal chemistry. Catalytic groups are localized via a tethered ligand either to DNA …