The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …
small-molecule probes. These molecular tools have been widely applied for interrogating …
μMap-Red: proximity labeling by red light photocatalysis
Modern proximity labeling techniques have enabled significant advances in understanding
biomolecular interactions. However, current tools primarily utilize activation modes that are …
biomolecular interactions. However, current tools primarily utilize activation modes that are …
Recent progress and challenges of photocatalytic CO2 conversion into value-added multi-carbon products
C Li, J Wang, L Tong, Y Wang, P Zhang, M Zhu… - Coordination Chemistry …, 2024 - Elsevier
In recently years, photocatalytic CO 2 conversion into the value-added chemicals represents
a promising approach to relieve the current energy and environmental problems, because it …
a promising approach to relieve the current energy and environmental problems, because it …
Improved transition metal photosensitizers to drive advances in photocatalysis
To function effectively in a photocatalytic application, a photosensitizer's light absorption,
excited-state lifetime, and redox potentials, both in the ground state and excited state, are …
excited-state lifetime, and redox potentials, both in the ground state and excited state, are …
Orange Light-Driven C(sp2)–C(sp3) Cross-Coupling via Spin-Forbidden Ir(III) Metallaphotoredox Catalysis
KA Xie, E Bednarova, CL Joe, C Lin… - Journal of the …, 2023 - ACS Publications
We report the development and characterization of a library of Ir (III) photocatalysts capable
of undergoing spin-forbidden excitation (SFE) under orange light irradiation (595 nm). These …
of undergoing spin-forbidden excitation (SFE) under orange light irradiation (595 nm). These …
A genetically encoded photoproximity labeling approach for mapping protein territories
Studying dynamic biological processes requires approaches compatible with the lifetimes of
the biochemical transactions under investigation, which can be very short. We describe a …
the biochemical transactions under investigation, which can be very short. We describe a …
Switchable DNA Catalysts for Proximity Labeling at Sites of Protein–Protein Interactions
AN Ogorek, X Zhou, JD Martell - Journal of the American Chemical …, 2023 - ACS Publications
Proximity labeling (PL) has emerged as a powerful approach to elucidate proteomes within
a defined radius around a protein of interest (POI). In PL, a catalyst is attached to the POI …
a defined radius around a protein of interest (POI). In PL, a catalyst is attached to the POI …
Photocatalytic Activation of Aryl (trifluoromethyl) Diazos to Carbenes for High-Resolution Protein Labeling with Red Light
DC Cabanero, SK Kariofillis, AC Johns… - Journal of the …, 2024 - ACS Publications
State-of-the-art methods in photoproximity labeling center on the targeted generation and
capture of short-lived reactive intermediates to provide a snapshot of local protein …
capture of short-lived reactive intermediates to provide a snapshot of local protein …
Ligand-directed photocatalysts and far-red light enable catalytic bioorthogonal uncaging inside live cells
Described are ligand-directed catalysts for live-cell, photocatalytic activation of
bioorthogonal chemistry. Catalytic groups are localized via a tethered ligand either to DNA …
bioorthogonal chemistry. Catalytic groups are localized via a tethered ligand either to DNA …