Simple Summary Beyond mutations, epigenetic changes have been described as drivers for
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …

In the past few decades, the development of heat shock protein 90 (Hsp90) inhibitors for
cancer treatment has not stopped. About twenty compounds have been evaluated in the …

Heat shock protein 90, also known as Hsp90, is an extensively preserved molecular
chaperone that performs a critical function in organizing various biological pathways and …

The development of drugs for the treatment of advanced prostate cancer (PCA) remains a
challenging task. In this study we have designed, synthesized and tested twenty-nine novel …

Punica granatum L.(pomegranate) fruit is known to be an important source of bioactive
phenolic compounds belonging to hydrolysable tannins. Pomegranate extracts have shown …

Heterocycles are being playing an important role in cancer treatment for years. Currently, a
number of anticancer agents are available on market, but concerns such as less …

HDAC6 and Hsp90, existing as a cytosolic complex play an important role in maintaining the
protein homeostasis. The interplay of HDAC6 and Hsp90 has attracted wide attention due to …

Heat shock protein 90 (Hsp90) is a promising target in tumor biology as required for
oncogenic protein kinases. The Hsp90‐alpha N‐domain delineates an ATP binding pocket; …