The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Mechanical forces are fundamental in cardiovascular biology, and deciphering the
mechanisms by which they act remains a testing frontier in cardiovascular research. Here …

Mechanotransduction has a key role in vascular development, physiology, and disease
states. Piezo1 is a mechanosensitive (MS) nonselective cationic channel that occurs in …

The conversion of force into an electrical cellular signal is mediated by the opening of
different types of mechanosensitive ion channels (MSCs), including TREK/TRAAK K 2P …

Hemodynamic overload induces pathological cardiac hypertrophy, which is an independent
risk factor for intractable heart failure in long run. Beyond neurohumoral regulation …

Thrombosis is the leading complication of common human disorders including diabetes,
coronary heart disease, and infection and remains a global health burden. Current …

Hemodynamic overload and dysregulation of cellular metabolism are involved in
development of calcific aortic valve disease (CAVD). However, how mechanical stress …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

Touch, hearing, and blood pressure regulation require mechanically gated ion channels that
convert mechanical stimuli into electrical currents. One such channel is Piezo1, which plays …

Abstract Purpose of Review: Atherosclerosis is the principal cause of cardiovascular
diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an …