Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …

Angiogenesis is a hallmark of cancer and is required for tumor growth and progression.
Antiangiogenic therapy has been revolutionarily developing and was approved for the …

Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

Renal cell carcinoma (RCC) is the most common form of kidney cancer. It is categorized into
various subtypes, with clear cell RCC (ccRCC) representing about 85% of all RCC tumors …

The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch
signaling pathway is one of the most commonly activated signaling pathways in cancer …

The Notch signaling pathway regulates developmental cell-fate decisions and has recently
also been linked to inflammatory diseases. Although therapies targeting Notch signaling in …

Angiogenesis, the recruitment of new blood vessels, is a critical process for the growth,
expansion, and metastatic dissemination of developing tumors. Three types of cells make up …

Simple Summary Renal cell carcinoma is particularly characterized by its high
vascularization and dense immune cells infiltration. The angiogenesis blockade in …

The DLL/Notch signaling pathway plays an important role in cancer as a key driver in
maintaining cancer stemness and inducing tumor angiogenesis. Many different types of …

We present a mathematical model for vascular tumor growth. We use phase fields to model
cellular growth and reaction-diffusion equations for the dynamics of angiogenic factors and …