The diversified role of mitochondria in ferroptosis in cancer

Y Liu, S Lu, L Wu, L Yang, L Yang, J Wang - Cell death & disease, 2023 - nature.com
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …

Ferroptosis and cancer: mitochondria meet the “iron maiden” cell death

AM Battaglia, R Chirillo, I Aversa, A Sacco, F Costanzo… - Cells, 2020 - mdpi.com
Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

Mitochondria regulation in ferroptosis

H Wang, C Liu, Y Zhao, G Gao - European journal of cell biology, 2020 - Elsevier
Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe
lipid peroxidation relying on reactive oxygen species (ROS) generation and iron overload …

Ferroptosis mediates cuprizone-induced loss of oligodendrocytes and demyelination

P Jhelum, E Santos-Nogueira, W Teo… - Journal of …, 2020 - Soc Neuroscience
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a
copper chelator, is widely used to study demyelination and remyelination in the CNS, in the …

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

EI Azzam, JP Jay-Gerin, D Pain - Cancer letters, 2012 - Elsevier
Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure
through direct interactions of radiation with target macromolecules or via products of water …

Mitochondria‐targeted antioxidants

AO Oyewole, MA Birch‐Machin - The FASEB Journal, 2015 - Wiley Online Library
Redox homeostasis is maintained by the antioxidant defense system, which is responsible
for eliminating a wide range of oxidants, including reactive oxygen species (ROS), lipid …

Function and biogenesis of iron–sulphur proteins

R Lill - Nature, 2009 - nature.com
Abstract Iron–sulphur (Fe–S) clusters have long been recognized as essential and versatile
cofactors of proteins involved in catalysis, electron transport and sensing of ambient …

Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives

EA Jankowska, S von Haehling, SD Anker… - European heart …, 2013 - academic.oup.com
Iron is a micronutrient essential for cellular energy and metabolism, necessary for
maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with …

Iron deficiency: an ominous sign in patients with systolic chronic heart failure

EA Jankowska, P Rozentryt, A Witkowska… - European heart …, 2010 - academic.oup.com
Aims Beyond erythropoiesis, iron is involved in numerous biological processes crucial for
maintenance of homeostasis. Patients with chronic heart failure (CHF) are prone to develop …

Customized carbon dots with predictable optical properties synthesized at room temperature guided by machine learning

Q Hong, XY Wang, YT Gao, J Lv, BB Chen… - Chemistry of …, 2022 - ACS Publications
Fluorescent carbon dots (CDs) have been increasingly used in fluorescence detection and
imaging based on their tunable fluorescence (FL) and resistance to photobleaching …