Background Unexplained chronic cough (UCC) causes significant impairments in quality of
life. Effective assessment and treatment approaches are needed for UCC. Methods This …

Chronic refractory cough (CRC) is defined as a cough that persists despite guideline based
treatment. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a …

These guidelines incorporate the recent advances in chronic cough pathophysiology,
diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella …

Background We performed systematic reviews using the population, intervention,
comparison, outcome (PICO) format to answer the following key clinical question: Are the …

Background We updated the 2006 ACCP clinical practice guidelines for management of
reflux-cough syndrome. Methods Two population, intervention, comparison, outcome (PICO) …

Importance Gefapixant represents an emerging therapy for patients with refractory or
unexplained chronic cough. Objective To evaluate the efficacy and tolerability of gefapixant …

Terminology used to define clinical cough is based on features such as duration, underlying
causes, and associated characteristics such as whether the cough is “dry” or “productive.” …

In children and adults, chronic cough is a common symptom presenting to health
professionals worldwide. It is internationally accepted that children with chronic cough …

Purpose This analysis assesses clinical characteristics of patients with refractory chronic
cough (RCC) or unexplained chronic cough (UCC) enrolled in a phase 2 study to better …

Background We hypothesized that addressing anxiety and depressive mood disorders will
improve chronic cough severity and cough quality of life (CQOL). Methods Major tenets of …