Microbial infections are controlled by host inflammatory responses that are initiated by
innate immune receptors after recognition of conserved microbial products. As inflammation …

Although many studies have been exploring the mechanisms driving NETs formation, much
less attention has been paid to the degradation and elimination of these structures. The …

Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a
highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and …

Objective: Macrophages are immune cells, capable to remodel the extracellular matrix,
which can harbor extracellular DNA incorporated into neutrophil extracellular traps (NETs) …

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

The Class I phosphoinositide 3-kinases (PI3Ks) are a group of heterodimeric lipid kinases
that regulate crucial cellular processes including proliferation, survival, growth, and …

Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …

Mussels (Mytilus galloprovincialis) are filter feeder bivalves that are constantly in contact
with a wide range of microorganisms, some of which are potentially pathogenic. How …

Graft versus host disease (GVHD) represents the major complication after allogeneic
hematopoietic stem cell transplantation (Allo-SCT). GVHD-prone patients rely on GVHD …

Protein misfolding and accumulation defines a prevailing feature of many
neurodegenerative disorders, finally resulting in the formation of toxic intra-and extracellular …