SE translocation (SET) is a cancer‐promoting factor whose expression is upregulated in
many cancers. High SET expression positively correlates with a poor cancer prognosis …

Chronic neutrophilic leukemia (CNL) is a rare type of myeloproliferative neoplasm (MPN).
Due to its nonspecific clinical symptoms and lack of specific molecular markers, it was …

SETBP1 is a potential epigenetic regulator whose hotspot mutations preventing proteasomal
degradation are recurrently detected in myeloid malignancies with poor prognosis. It is …

Abstract SET binding protein 1 (SETBP1) plays crucial roles in various biological processes;
however, its involvement in cancer immune checkpoint inhibitor (ICI) treatments has never …

The SET binding protein 1 (SETBP1) gene encodes a transcription factor (TF) involved in
various cellular processes. Variants in SETBP1 can result in three different diseases …

SETBP1 mutations are found in various clonal myeloid disorders. However, it is unclear
whether they can initiate leukemia, because SETBP1 mutations typically appear as later …

Identification of genomic signatures with consistent clinicopathological features in
myelodysplastic/myeloproliferative neoplasm (MDS/MPN) is critical for improved diagnosis …

CSF3R activating mutation is a genetic hallmark of chronic neutrophilic leukemia (CNL), and
is also present in a subset of atypical chronic myeloid leukemia (aCML), but infrequent in …

Background Atypical chronic myeloid leukemia (aCML) is a BCR:: ABL1 negative
myelodysplastic/myeloproliferative neoplasm with poor overall survival. Some patients can …

Activating mutations in the extracellular domain of colony stimulating factor 3 receptor
(CSF3R, aka GCSFR) are present in an overwhelming majority of patients with chronic …