Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …
Phage therapy in the management of urinary tract infections: a comprehensive systematic review
AM Al-Anany, PB Hooey, JD Cook, LL Burrows… - Phage, 2023 - liebertpub.com
Urinary tract infections (UTIs) are a problem worldwide, affecting almost half a billion people
each year. Increasing antibiotic resistance and limited therapeutic options have led to the …
each year. Increasing antibiotic resistance and limited therapeutic options have led to the …
Compassionate use of bacteriophages for failed persistent infections during the first 5 years of the Israeli phage therapy center
The use of bacteriophages (phages) is reemerging as a potential treatment option for
antibiotic-resistant or nonresolving bacterial infections. Phages are bacteria-specific viruses …
antibiotic-resistant or nonresolving bacterial infections. Phages are bacteria-specific viruses …
[HTML][HTML] Phage Therapy: Targeting Intestinal Bacterial Microbiota for Treatment of Liver Diseases
J Fujiki, B Schnabl - JHEP Reports, 2023 - Elsevier
Phage therapy has been overshadowed by antibiotics for decades. However, it has been
revitalized as a powerful approach against antimicrobial-resistant bacteria. As the bacterial …
revitalized as a powerful approach against antimicrobial-resistant bacteria. As the bacterial …
[HTML][HTML] An overview of the current state of phage therapy for the treatment of biofilm-related infections
DP Pires, L Meneses, AC Brandao, J Azeredo - Current opinion in virology, 2022 - Elsevier
Bacterial biofilms are involved in many chronic and difficult-to-treat infections. Phage therapy
against infectious biofilms is becoming a promising strategy, as suggested by the increasing …
against infectious biofilms is becoming a promising strategy, as suggested by the increasing …
Phage therapy for nontuberculous mycobacteria: challenges and opportunities
GF Hatfull - Pulmonary Therapy, 2023 - Springer
Non-tuberculous mycobacterium (NTM) infections are often clinically challenging, with
lengthy antibiotic regimens that fail to resolve the infections with few good outcomes …
lengthy antibiotic regimens that fail to resolve the infections with few good outcomes …
A systematic review on the use of bacteriophage in treating Staphylococcus aureus and Pseudomonas aeruginosa infections in cystic fibrosis
J Singh, E Yeoh, DA Fitzgerald, H Selvadurai - Paediatric Respiratory …, 2023 - Elsevier
Background Respiratory infections caused by Staphylococcus aureus and Pseudomonas
aeruginosa are a major concern for cystic fibrosis (CF) patients due to increasing antibiotic …
aeruginosa are a major concern for cystic fibrosis (CF) patients due to increasing antibiotic …
Fitness trade-offs between phage and antibiotic sensitivity in phage-resistant variants: molecular action and insights into clinical applications for phage therapy
J Fujiki, K Nakamura, T Nakamura, H Iwano - International Journal of …, 2023 - mdpi.com
In recent decades, phage therapy has been overshadowed by the widespread use of
antibiotics in Western countries. However, it has been revitalized as a powerful approach …
antibiotics in Western countries. However, it has been revitalized as a powerful approach …
Biological properties of Staphylococcus virus ΦSA012 for phage therapy
J Fujiki, T Nakamura, K Nakamura, K Nishida… - Scientific Reports, 2022 - nature.com
Staphylococcus virus ΦSA012 has a wide host range and efficient lytic activity. Here, we
assessed the biological stability of ΦSA012 against temperature, freeze-thawing, and pH to …
assessed the biological stability of ΦSA012 against temperature, freeze-thawing, and pH to …
Phage lysins for intestinal microbiome modulation: current challenges and enabling techniques
I Pottie, R Vázquez Fernández, T Van de Wiele… - Gut …, 2024 - Taylor & Francis
The importance of the microbiota in the intestinal tract for human health has been
increasingly recognized. In this perspective, microbiome modulation, a targeted alteration of …
increasingly recognized. In this perspective, microbiome modulation, a targeted alteration of …