Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …

Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …

Matrix metalloproteinases (MMPs) have been implicated in diverse roles in breast cancer
development and progression. While many of the different MMPs expressed in breast cancer …

Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were
originally identified as endogenous inhibitors of matrixin and adamalysin endopeptidase …

Breast, lung, and pancreatic cancers collectively represent one third of all diagnosed tumors
and are responsible for almost 40% of overall cancer mortality. Despite improvements in …

Extracellular proteolysis and turnover are core processes of tissue homeostasis. The
predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase …

The members of the tissue inhibitor of metalloproteinase (TIMP) family (TIMP-1, 2, 3, 4) are
prominently appreciated as natural inhibitors of cancer-promoting metalloproteinases …

Cancer is one of the leading causes of death in patients worldwide, where invasion and
metastasis are directly responsible for this statement. Although cancer therapy has …

Degradation of the extracellular matrices in the human body is controlled by matrix
metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …