Therapeutic potential of matrix metalloproteinase inhibition in breast cancer
ES Radisky… - Journal of cellular …, 2017 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …
components of the extracellular matrix as well as many other soluble and cell‐associated …
[HTML][HTML] Matrix metalloproteinases as breast cancer drivers and therapeutic targets
ES Radisky, DC Radisky - Frontiers in bioscience (Landmark …, 2015 - ncbi.nlm.nih.gov
Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
[HTML][HTML] Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer
Matrix metalloproteinases (MMPs) have been implicated in diverse roles in breast cancer
development and progression. While many of the different MMPs expressed in breast cancer …
development and progression. While many of the different MMPs expressed in breast cancer …
Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer
D Peeney, Y Liu, C Lazaroff, S Gurung… - …, 2022 - academic.oup.com
Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were
originally identified as endogenous inhibitors of matrixin and adamalysin endopeptidase …
originally identified as endogenous inhibitors of matrixin and adamalysin endopeptidase …
[HTML][HTML] Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma
Breast, lung, and pancreatic cancers collectively represent one third of all diagnosed tumors
and are responsible for almost 40% of overall cancer mortality. Despite improvements in …
and are responsible for almost 40% of overall cancer mortality. Despite improvements in …
[HTML][HTML] Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9
S Coates-Park, C Lazaroff, S Gurung, J Rich… - Matrix Biology, 2023 - Elsevier
Extracellular proteolysis and turnover are core processes of tissue homeostasis. The
predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase …
predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase …
Functional disparities within the TIMP family in cancer: hints from molecular divergence
C Eckfeld, D Häußler, B Schoeps, CD Hermann… - Cancer and Metastasis …, 2019 - Springer
The members of the tissue inhibitor of metalloproteinase (TIMP) family (TIMP-1, 2, 3, 4) are
prominently appreciated as natural inhibitors of cancer-promoting metalloproteinases …
prominently appreciated as natural inhibitors of cancer-promoting metalloproteinases …
Flavonoids as regulators of TIMPs expression in cancer: Consequences, opportunities, and challenges
L Cayetano-Salazar, DA Nava-Tapia… - Life Sciences, 2022 - Elsevier
Cancer is one of the leading causes of death in patients worldwide, where invasion and
metastasis are directly responsible for this statement. Although cancer therapy has …
metastasis are directly responsible for this statement. Although cancer therapy has …
Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution
Degradation of the extracellular matrices in the human body is controlled by matrix
metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in …
metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in …
Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis
ES Radisky - Journal of Biological Chemistry, 2024 - ASBMB
A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …
cancer, shaped and reshaped by a complex network of extracellular proteases. These …