The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

Disruptions to dopamine and noradrenergic neurotransmission are noted in several
neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …

Ferroptosis, an iron-dependent nonapoptotic cell death, was referred in neurodegenerative
diseases, but its role in Parkinson's disease remains unclear. Here, we used ferric …

This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI
signal in the substantia nigra and their relation to clinical scores of disease severity in …

Background Development of reliable and accurate imaging biomarkers of dopaminergic cell
neurodegeneration is necessary to facilitate therapeutic drug trials in Parkinson's disease …

In Parkinson's disease, there is a progressive reduction in striatal dopaminergic function,
and loss of neuromelanin-containing dopaminergic neurons and increased iron deposition …

Parkinson's disease (PD) is a neurodegenerative synucleinopathy characterized by the
degeneration of neuromelanin (NM)-containing dopaminergic neurons and deposition of …

Historically, magnetic resonance imaging (MRI) has contributed little to the study of
Parkinson's disease (PD), but modern MRI approaches have unveiled several …

Diagnosing early stage Parkinson's disease (PD) is still a clinical challenge. Previous
studies using iron, neuromelanin (NM) or the Nigrosome-1 (N1) sign in the substantia nigra …

Background: Parkinson's disease (PD) is a progressive neurodegenerative disease whose
main neuropathological feature is the loss of dopaminergic neurons of the substantia nigra …