As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …

Implantable and ingestible biomedical electronic devices can be useful tools for detecting
physiological and pathophysiological signals, and providing treatments that cannot be done …

Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …

Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but
high-resolution manometry of human colonic motor function has revealed that our …

The role of short-chain fatty acids (SCFAs) in the control of colonic motility is controversial.
Germ-free (GF) mice are unable to produce these metabolites and serve as a model to study …

The parameters of heart rate variability (HRV) can non-invasively assess some autonomic
activities, and HRV is influenced by many bodily actions. Although parasympathetic activity …

Background High‐resolution colonic manometry gives an unprecedented window into motor
patterns of the human colon. Our objective was to characterize motor activities throughout …

Simultaneous pressure waves (SPWs) in manometry recordings of the human colon have
been associated with gas expulsion. Our hypothesis was that the SPW might be a critical …

Characterization of high-amplitude propagating pressure waves (HAPWs or HAPCs) plays a
key role in diagnosis of colon dysmotility using any type of colonic manometry. With the …

The proximal part of the colon offers opportunities to prolong the absorption window
following oral administration of a drug. In this work, we used computer simulations to …