Long-read technologies are overcoming early limitations in accuracy and throughput,
broadening their application domains in genomics. Dedicated analysis tools that take into …

Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Background: Data sets from long-read sequencing platforms (Oxford Nanopore
Technologies and Pacific Biosciences) allow for most prokaryote genomes to be completely …

Complete, accurate, cost-effective, and high-throughput reconstruction of bacterial genomes
for large-scale genomic epidemiological studies is currently only possible with hybrid …

Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of
noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma …

Over the past 25 years, the powerful combination of genome sequencing and bioinformatics
analysis has played a crucial role in interpreting information encoded in bacterial genomes …

With recent advances in sequencing technologies, it is now possible to obtain near-perfect
complete bacterial chromosome assemblies cheaply and efficiently by combining a long …

Sequencing technology is the most commonly used technology in molecular biology
research and an essential pillar for the development and applications of molecular biology …

Abstract Background The incidence of Gram-negative bloodstream infections (BSIs),
predominantly caused by Escherichia coli and Klebsiella species, continues to increase; …

Background Accurately identifying single-nucleotide polymorphisms (SNPs) from bacterial
sequencing data is an essential requirement for using genomics to track transmission and …