Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
M Cargnello, PP Roux - Microbiology and molecular biology …, 2011 - Am Soc Microbiol
The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
The RSK family of kinases: emerging roles in cellular signalling
R Anjum, J Blenis - Nature reviews Molecular cell biology, 2008 - nature.com
The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved
Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility …
Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility …
RIP1 kinase drives macrophage-mediated adaptive immune tolerance in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance and
immunotherapeutic resistance. We discovered upregulation of receptor-interacting …
immunotherapeutic resistance. We discovered upregulation of receptor-interacting …
Regulation and function of the RSK family of protein kinases
The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related
serine/threonine kinases that regulate diverse cellular processes, including cell growth …
serine/threonine kinases that regulate diverse cellular processes, including cell growth …
[PDF][PDF] The RSK factors of activating the Ras/MAPK signaling cascade
[Frontiers in Bioscience 13, 4258-4275, May 1, 2008] 4258 The RSK factors of activating the
Ras/MAPK signaling cascade Audrey Ca Page 1 [Frontiers in Bioscience 13, 4258-4275, May …
Ras/MAPK signaling cascade Audrey Ca Page 1 [Frontiers in Bioscience 13, 4258-4275, May …
Mitogen-activated protein kinases in mammalian oxidative stress responses
C Runchel, A Matsuzawa, H Ichijo - Antioxidants & redox signaling, 2011 - liebertpub.com
All aerobic organisms are exposed to oxidative stress during their lifetime and are required
to respond appropriately for maintenance of their survival and homeostasis. Sustained …
to respond appropriately for maintenance of their survival and homeostasis. Sustained …
Novel mechanisms of endothelial mechanotransduction
Atherosclerosis is a focal disease that develops preferentially where nonlaminar, disturbed
blood flow occurs, such as branches, bifurcations, and curvatures of large arteries …
blood flow occurs, such as branches, bifurcations, and curvatures of large arteries …
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis
Background—Diabetes mellitus is a major risk factor for cardiovascular mortality by
increasing endothelial cell (EC) dysfunction and subsequently accelerating atherosclerosis …
increasing endothelial cell (EC) dysfunction and subsequently accelerating atherosclerosis …
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells
MD Bareford, MA Park, A Yacoub, HA Hamed, Y Tang… - Cancer research, 2011 - AACR
Pemetrexed (ALIMTA, Lilly) is a folate antimetabolite that has been approved by the US
Food and Drug Administration for the treatment of non–small cell lung cancer and has been …
Food and Drug Administration for the treatment of non–small cell lung cancer and has been …
Oncogenic signaling of MEK5-ERK5
VT Hoang, TJ Yan, JE Cavanaugh, PT Flaherty… - Cancer letters, 2017 - Elsevier
Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including
proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK …
proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK …