[HTML][HTML] Precision medicine for gastrointestinal cancer: Recent progress and future perspective
T Matsuoka, M Yashiro - World journal of gastrointestinal oncology, 2020 - ncbi.nlm.nih.gov
Gastrointestinal (GI) cancer has a high tumor incidence and mortality rate worldwide.
Despite significant improvements in radiotherapy, chemotherapy, and targeted therapy for GI …
Despite significant improvements in radiotherapy, chemotherapy, and targeted therapy for GI …
[HTML][HTML] Targeted variant prevalence of FBXW7 gene mutation in colorectal carcinoma propagation. The first systematic review and meta-analysis
HA Afolabi, SM Salleh, Z Zakaria, NM Nafi… - Heliyon, 2024 - cell.com
FBXW7 is a tumour suppressor gene that functions as E3-ubiquitin-ligase, targeting
numerous oncoproteins for degradation, ie, Cyclin-E, c-Myc, and Notch. FBXW7 performs a …
numerous oncoproteins for degradation, ie, Cyclin-E, c-Myc, and Notch. FBXW7 performs a …
Early change in circulating tumor DNA as a potential predictor of response to chemotherapy in patients with metastatic colorectal cancer
H Osumi, E Shinozaki, K Yamaguchi, H Zembutsu - Scientific reports, 2019 - nature.com
The impact of ctDNA changes after chemotherapy on the clinical outcomes of patients with
metastatic colorectal cancer (mCRC) remains unclear. The present study evaluated the …
metastatic colorectal cancer (mCRC) remains unclear. The present study evaluated the …
KRAS/NRAS Mutations Associated with Distant Metastasis and BRAF/PIK3CA Mutations Associated with Poor Tumor Differentiation in Colorectal Cancer
J Zeng, W Fan, J Li, G Wu, H Wu - International Journal of General …, 2023 - Taylor & Francis
Background The occurrence, progression, and prognosis of colorectal cancer (CRC) are
regulated by EGFR-mediated signaling pathways. However, the relationship between the …
regulated by EGFR-mediated signaling pathways. However, the relationship between the …
Mutation in BRAF and SMAD4 associated with resistance to neoadjuvant chemoradiation therapy in locally advanced rectal cancer
D Jiang, X Wang, Y Wang, D Philips, W Meng, M Xiong… - Virchows Archiv, 2019 - Springer
Our study was done in order to identify novel molecular markers to predict which locally
advanced rectal cancers (LARCs) might be resistant to neoadjuvant chemoradiotherapy …
advanced rectal cancers (LARCs) might be resistant to neoadjuvant chemoradiotherapy …
Effect of tumor location on clinicopathological and molecular markers in colorectal cancer in eastern China patients: an analysis of 2,356 cases
Y Song, L Wang, W Ran, G Li, Y Xiao, X Wang… - Frontiers in …, 2020 - frontiersin.org
Colorectal cancer (CRC) has become a major health concern in China due to its increasing
incidence and mortality. This study aimed to clarify the relationship between tumor locations …
incidence and mortality. This study aimed to clarify the relationship between tumor locations …
Tissue gene mutation profiles in patients with colorectal cancer and their clinical implications
J Ye, M Lin, C Zhang, X Zhu, S Li, H Liu… - Biomedical …, 2020 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most common types of cancer in the world, and
targeted therapy is frequently used in the clinical management of the disease. A complete …
targeted therapy is frequently used in the clinical management of the disease. A complete …
Development, implementation and assessment of molecular diagnostics by next generation sequencing in personalized treatment of cancer: experience of a public …
J Simarro, R Murria, G Pérez-Simó, M Llop… - Cancers, 2019 - mdpi.com
The establishment of precision medicine in cancer patients requires the study of several
biomarkers. Single-gene testing approaches are limited by sample availability and …
biomarkers. Single-gene testing approaches are limited by sample availability and …
Distinct Driver Pathway Enrichments and a High Prevalence of TSC2 Mutations in Right Colon Cancer in Chile: A Preliminary Comparative Analysis
C Tapia-Valladares, G Valenzuela, E González… - International Journal of …, 2024 - mdpi.com
Colorectal cancer (CRC) is the second leading cause of cancer deaths globally. While
ethnic differences in driver gene mutations have been documented, the South American …
ethnic differences in driver gene mutations have been documented, the South American …
[HTML][HTML] Relationship between mismatch repair protein, RAS, BRAF, PIK3CA gene expression and clinicopathological characteristics in elderly colorectal cancer …
JZ Fan, GF Wang, XB Cheng, ZH Dong… - World Journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND Colorectal cancer (CRC) is common in elderly patients. Mismatch repair
(MMR) protein deletion is one of the causes of CRC. The RAS (KRAS/NRAS), BRAF, and …
(MMR) protein deletion is one of the causes of CRC. The RAS (KRAS/NRAS), BRAF, and …