[HTML][HTML] A red carpet for iron metabolism
200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …
Handling heme: The mechanisms underlying the movement of heme within and between cells
Heme is an essential cofactor and signaling molecule required for virtually all aerobic life.
However, excess heme is cytotoxic. Therefore, heme must be safely transported and …
However, excess heme is cytotoxic. Therefore, heme must be safely transported and …
One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers
IG Chambers, MM Willoughby, I Hamza… - Biochimica et Biophysica …, 2021 - Elsevier
Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with
biological membranes. The very same properties of heme that nature exploits to support life …
biological membranes. The very same properties of heme that nature exploits to support life …
Role of heme oxygenase as a modulator of heme-mediated pathways
JC Duvigneau, H Esterbauer, AV Kozlov - Antioxidants, 2019 - mdpi.com
The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …
The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation
Heme is an iron-containing porphyrin of vital importance for cell energetic metabolism. High
rates of heme synthesis are commonly observed in proliferating cells. Moreover, the cell …
rates of heme synthesis are commonly observed in proliferating cells. Moreover, the cell …
Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis
Heme is required for cell respiration and survival. Nevertheless, its intracellular levels need
to be finely regulated to avoid heme excess, which may catalyze the production of reactive …
to be finely regulated to avoid heme excess, which may catalyze the production of reactive …
Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors
A Moore, MP Busch, K Dziewulska, RO Francis… - Journal of Biological …, 2022 - ASBMB
The red blood cell (RBC)-Omics study, part of the larger NHLBI-funded Recipient
Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic …
Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic …
Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis
Abstract The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a
transmembrane heme exporter essential for embryonic vascular development. However, the …
transmembrane heme exporter essential for embryonic vascular development. However, the …
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
HTT Ha, VK Sukumar, JWB Chua, DT Nguyen… - Cellular and Molecular …, 2024 - Springer
MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small
molecules. Two isoforms of MFSD7b have been identified and they are reported to be heme …
molecules. Two isoforms of MFSD7b have been identified and they are reported to be heme …
[HTML][HTML] GAPDH is involved in the heme-maturation of myoglobin and hemoglobin
B Tupta, E Stuehr, MP Sumi, EA Sweeny… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
GAPDH, a heme chaperone, has been previously implicated in the incorporation of heme
into iNOS and soluble guanylyl cyclase (sGC). Since sGC is critical for myoglobin (Mb) heme …
into iNOS and soluble guanylyl cyclase (sGC). Since sGC is critical for myoglobin (Mb) heme …