[HTML][HTML] A red carpet for iron metabolism

MU Muckenthaler, S Rivella, MW Hentze, B Galy - Cell, 2017 - cell.com
200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Handling heme: The mechanisms underlying the movement of heme within and between cells

RK Donegan, CM Moore, DA Hanna… - Free Radical Biology and …, 2019 - Elsevier
Heme is an essential cofactor and signaling molecule required for virtually all aerobic life.
However, excess heme is cytotoxic. Therefore, heme must be safely transported and …

One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers

IG Chambers, MM Willoughby, I Hamza… - Biochimica et Biophysica …, 2021 - Elsevier
Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with
biological membranes. The very same properties of heme that nature exploits to support life …

Role of heme oxygenase as a modulator of heme-mediated pathways

JC Duvigneau, H Esterbauer, AV Kozlov - Antioxidants, 2019 - mdpi.com
The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …

The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation

V Fiorito, AL Allocco, S Petrillo, E Gazzano, S Torretta… - Cell reports, 2021 - cell.com
Heme is an iron-containing porphyrin of vital importance for cell energetic metabolism. High
rates of heme synthesis are commonly observed in proliferating cells. Moreover, the cell …

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis

S Petrillo, D Chiabrando, T Genova, V Fiorito… - Cell Death & …, 2018 - nature.com
Heme is required for cell respiration and survival. Nevertheless, its intracellular levels need
to be finely regulated to avoid heme excess, which may catalyze the production of reactive …

Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors

A Moore, MP Busch, K Dziewulska, RO Francis… - Journal of Biological …, 2022 - ASBMB
The red blood cell (RBC)-Omics study, part of the larger NHLBI-funded Recipient
Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic …

Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis

S Petrillo, F De Giorgio, F Bertino, F Garello, V Bitonto… - Angiogenesis, 2023 - Springer
Abstract The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a
transmembrane heme exporter essential for embryonic vascular development. However, the …

Mfsd7b facilitates choline transport and missense mutations affect choline transport function

HTT Ha, VK Sukumar, JWB Chua, DT Nguyen… - Cellular and Molecular …, 2024 - Springer
MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small
molecules. Two isoforms of MFSD7b have been identified and they are reported to be heme …

[HTML][HTML] GAPDH is involved in the heme-maturation of myoglobin and hemoglobin

B Tupta, E Stuehr, MP Sumi, EA Sweeny… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
GAPDH, a heme chaperone, has been previously implicated in the incorporation of heme
into iNOS and soluble guanylyl cyclase (sGC). Since sGC is critical for myoglobin (Mb) heme …