Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …

Psoriasis is a systemic inflammatory disease associated with increased risk of comorbidities,
such as psoriatic arthritis, Crohn's disease, malignancy, obesity, and cardiovascular …

Caroline Gordon1, 2, 3, Maame-Boatemaa Amissah-Arthur1, Mary Gayed1, 3, Sue Brown4,
Ian N. Bruce5, 6, David D'Cruz7, Benjamin Empson8, Bridget Griffiths9, David Jayne10, 11 …

Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable
presentations, course and prognosis. We sought to develop evidence-based …

Objectives: To develop evidence-based recommendations for the use of methotrexate in
daily clinical practice in rheumatic disorders. Methods: 751 rheumatologists from 17 …

The past century has been characterized by intensive efforts, within both academia and the
pharmaceutical industry, to introduce new treatments to individuals with rheumatic …

Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease of
unknown etiology, whose hallmark is the production of autoantibodies. B cells are promising …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant
clinical heterogeneity. Recent advances in our understanding of the genetic, molecular, and …

MTX is an immunosuppressant drug that occupies a key place in the management of many
autoimmune and inflammatory skin diseases. Although MTX has been widely prescribed in …

Methotrexate (MTX) is currently considered, among disease-modifying anti-rheumatic drugs
(DMARDs), the 'anchor-drug'in the treatment of rheumatoid arthritis. In the last 25 years …