Atezolizumab-bevacizumab plus Y-90 TARE for the treatment of hepatocellular carcinoma: preclinical rationale and ongoing clinical trials

A Di Federico, A Rizzo, R Carloni… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The treatment algorithm of advanced hepatocellular carcinoma (HCC) has
evolved since the introduction of immunotherapy. The IMbrave150 trial set atezolizumab …

Applications of graphene-based electrochemical and optical biosensors in early detection of cancer biomarkers

F Arshad, F Nabi, S Iqbal, RH Khan - Colloids and Surfaces B: Biointerfaces, 2022 - Elsevier
Graphene is a one-atom-thick carbon compound, which holds promises for detecting cancer
biomarkers along with its derivatives. The atom-wide graphene layer is ideal for cancer …

Anlotinib: a novel targeted drug for bone and soft tissue sarcoma

S Li - Frontiers in oncology, 2021 - frontiersin.org
Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant
tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas …

The application of nanobody in CAR-T therapy

C Bao, Q Gao, LL Li, L Han, B Zhang, Y Ding, Z Song… - Biomolecules, 2021 - mdpi.com
Chimeric antigen receptor (CAR) T therapy represents a form of immune cellular therapy
with clinical efficacy and a specific target. A typical chimeric antigen receptor (CAR) …

VEGF signaling: Role in angiogenesis and beyond

P Shaw, SKD Dwivedi, R Bhattacharya… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …

Atherosclerosis, diabetes mellitus, and cancer: common epidemiology, shared mechanisms, and future management

V Katsi, I Papakonstantinou, K Tsioufis - International Journal of …, 2023 - mdpi.com
The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells

H Shen, H Yu, Q Li, Y Wei, J Fu, H Dong… - Acta Pharmacologica …, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is emerging as an epidemic risk factor for
hepatocellular carcinoma (HCC). The progression of NAFLD to HCC is closely associated …

Recent advances in targeted drug delivery systems for resistant colorectal cancer

M Sharifi-Azad, M Fathi, WC Cho, A Barzegari… - Cancer Cell …, 2022 - Springer
Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and
morality rate are rising and poses an important threat to the public health. It is known that …

Exploring the intracrine functions of VEGF-A

S Wiszniak, Q Schwarz - Biomolecules, 2021 - mdpi.com
Vascular endothelial growth factor A (VEGF-A or VEGF) is a highly conserved secreted
signalling protein best known for its roles in vascular development and angiogenesis. Many …

Updates on systemic therapy for hepatocellular carcinoma

P Ntellas, I Chau - American Society of Clinical Oncology Educational …, 2024 - ascopubs.org
This review explores the dynamic landscape of hepatocellular carcinoma (HCC) treatment,
emphasizing on recent developments across various stages and therapeutic approaches …