The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Epigenetic memory, in particular DNA methylation, is established during development in
differentiating cells and must be erased to create naïve (induced) pluripotent stem cells. The …

Zinc is a critical component in a number of conserved processes that regulate female germ
cell growth, fertility, and pregnancy. During follicle development, a sufficient intracellular …

DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …

Background It is well established that obesity is associated with dysregulation of the ratio
between the two major adipokines leptin and adiponectin. Furthermore, it was recently …

The co-option of endogenous retroviruses (ERVs) is increasingly recognized as a recurrent
theme in placental biology, which has far-reaching implications for our understanding of …

As the maternal–foetal interface, the placenta is essential for the establishment and
progression of healthy pregnancy, regulating both foetal growth and maternal adaptation to …

Trophoblast stem cells (TSCs) retain the capacity to self-renew indefinitely and harbour the
potential to differentiate into all trophoblast subtypes of the placenta. Recent studies have …

At the time of implantation in the maternal uterus, the mouse blastocyst possesses an inner
cell mass comprising two lineages: epiblast (Epi) and primitive endoderm (PrE) …