Objective: To systematically review evidence bearing on the management of patients with
amyotrophic lateral sclerosis (ALS). Methods: The authors analyzed studies from 1998 to …

Amyotrophic lateral sclerosis (known in the UK as motor neuron disease) is a devastating
illness with uncertain pathogenesis. In this Seminar, we review its natural history, clinical …

Background Minocycline has anti-apoptotic and anti-inflammatory effects in vitro, and
extends survival in mouse models of some neurological conditions. Several trials are …

Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …

Neuroinflammation is a characteristic of pathologically affected tissue in several
neurodegenerative disorders. These changes can be observed in the brainstem and spinal …

Pain is a largely neglected symptom in patients with amyotrophic lateral sclerosis (ALS)
although it is reported by most of these patients. It occurs at all stages of the disease and can …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. To
determine predictors of survival, we studied different parameters in our ALS Database …

Amyotrophic lateral sclerosis (ALS) is an age-related neurodegenerative disorder that is
believed to have complex genetic and environmental influences in the pathogenesis, but …

Background: Mitochondrial dysfunction occurs early in the course of ALS, and the
mitochondria may be an important site for therapeutic intervention. Creatine stabilizes the …

Objective: To determine whether the Amyotrophic Lateral Sclerosis Functional Rating Scale–
revised (ALSFRSr), a predictor of survival time in ALS clinical trials, predicts survival time in …