Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future
Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
A brief history of organoids
C Corrò, L Novellasdemunt… - American Journal of …, 2020 - journals.physiology.org
In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …
diseases. Although the conventional monolayer cell cultures have been widely used in the …
Lysosomal dysfunction in neurodegeneration: emerging concepts and methods
V Udayar, Y Chen, E Sidransky, R Jagasia - Trends in neurosciences, 2022 - cell.com
The understanding of lysosomes has come a long way since the initial discovery of their role
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …
In vitro Models of Neurodegenerative Diseases
A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
Microglia-containing human brain organoids for the study of brain development and pathology
W Zhang, J Jiang, Z Xu, H Yan, B Tang, C Liu… - Molecular …, 2023 - nature.com
Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …
brain development and homeostasis. Increasing evidence has implicated microglia …
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
S Sabate‐Soler, SL Nickels, C Saraiva, E Berger… - Glia, 2022 - Wiley Online Library
The human brain is a complex, three‐dimensional structure. To better recapitulate brain
complexity, recent efforts have focused on the development of human‐specific midbrain …
complexity, recent efforts have focused on the development of human‐specific midbrain …
Bioengineering approaches for the advanced organoid research
Recent advances in 3D cell culture technology have enabled scientists to generate stem cell
derived organoids that recapitulate the structural and functional characteristics of native …
derived organoids that recapitulate the structural and functional characteristics of native …
Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease
J Sidhaye, JA Knoblich - Cell Death & Differentiation, 2021 - nature.com
Understanding etiology of human neurological and psychiatric diseases is challenging.
Genomic changes, protracted development, and histological features unique to human brain …
Genomic changes, protracted development, and histological features unique to human brain …