Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

Aging is the main risk factor for neurodegenerative diseases. In aging, microglia undergoes
phenotypic changes compatible with their activation. Glial activation can lead to …

Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …

Targeting self-renewal is an important goal in cancer therapy and recent studies have
focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs) …

The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …

Targeted therapy against the programmed cell death ligand-1 (PD-L1) blockade holds
considerable promise for the treatment of different tumor types; however, little effect has …

In amyotrophic lateral sclerosis (ALS), immune cells and glia contribute to motor neuron
(MN) degeneration. We report the presence of NK cells in post-mortem ALS motor cortex …

Histological analysis of biological tissues by mechanical sectioning is significantly time‐
consuming and error‐prone due to loss of important information during sample slicing. In the …

The mechanisms of communication between the brain and the immune cells are still largely
unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate …