Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

The p53 guardian of the genome is inactivated in the majority of cancers, mostly through
missense mutations that cause single residue changes in the DNA binding core domain of …

We have identified a homolog of the mammalian p53 tumor suppressor protein in the
nematode Caenorhabditis elegans that is expressed ubiquitously in embryos. The gene …

The mechanisms that regulate the growth of the brain remain unclear. We show that Sonic
hedgehog (Shh) is expressed in a layer-specific manner in the perinatal mouse neocortex …

In this study, we outline a regulatory network that involves the p53 tumor suppressor family
and the Wnt pathway acting together with the TGF-β pathway in mesendodermal …

A surprisingly large and unrelated number of human tumors depend on sustained
HEDGEHOG-GLI (HH-GLI) signaling for growth. This includes cancers of the skin, brain …

Most human cancers harbor mutations in the gene encoding p53. As a result, research on
p53 in the past few decades has focused primarily on its role as a tumor suppressor. One …

Identification and characterization of p53 target genes would lead to a better understanding
of p53 functions and p53-mediated signaling pathways. Two putative p53 binding sites were …

How cell numbers are determined is not understood. Hedgehog‐Gli activity is involved in
precursor cell proliferation and stem cell self‐renewal, and its deregulation sustains the …