The expanding role of pyridine and dihydropyridine scaffolds in drug design
Y Ling, ZY Hao, D Liang, CL Zhang… - Drug design …, 2021 - Taylor & Francis
Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …
drug design, primarily due to their profound effect on pharmacological activity, which has led …
Deep eutectic solvents (DESs) as eco-friendly and sustainable solvent/catalyst systems in organic transformations
S Khandelwal, YK Tailor, M Kumar - Journal of Molecular Liquids, 2016 - Elsevier
The development of efficient and environmentally benign synthetic protocols has attracted
increasing interest in modern organic syntheses in view of the growing concern over the …
increasing interest in modern organic syntheses in view of the growing concern over the …
Magnesium-catalyzed hydroboration of pyridines
M Arrowsmith, MS Hill, T Hadlington… - …, 2011 - ACS Publications
Reaction of catalytic quantities of a β-diketiminato n-butylmagnesium complex with pinacol–
borane in the presence of pyridine derivatives provides facile access to borylated …
borane in the presence of pyridine derivatives provides facile access to borylated …
[HTML][HTML] 1, 4-Dihydropyridine: Synthetic advances, medicinal and insecticidal properties
A Parthiban, P Makam - RSC advances, 2022 - pubs.rsc.org
1, 4-Dihydropyridine (1, 4-DHP) is one of the foremost notable organic scaffolds with diverse
pharmaceutical applications. This study will highlight recent accomplishments in the …
pharmaceutical applications. This study will highlight recent accomplishments in the …
Atom-efficient regioselective 1, 2-dearomatization of functionalized pyridines by an earth-abundant organolanthanide catalyst
Developing earth-abundant, non-platinum metal catalysts for high-value chemical
transformations is a critical challenge to contemporary chemical synthesis. Dearomatization …
transformations is a critical challenge to contemporary chemical synthesis. Dearomatization …
Metal-free regio-and chemoselective hydroboration of pyridines catalyzed by 1, 3, 2-diazaphosphenium triflate
N-Heterocyclic phosphenium triflates (NHP-OTf) 1 serve as efficient catalysts for the regio-
and chemoselective hydroboration of pyridines under ambient condition with good …
and chemoselective hydroboration of pyridines under ambient condition with good …
[HTML][HTML] Novel polyhydroquinoline-hydrazide-linked Schiff's base derivatives: multistep synthesis, antimicrobial, and calcium-channel-blocking activities
Polyhydroquinoline (PHQ) are the unsymmetrical Hantzsch derivatives of 1, 4-
dihydropyridines with several biological applications. In this work, twenty-five (3–27) new …
dihydropyridines with several biological applications. In this work, twenty-five (3–27) new …
Synthesis, Structure, and Reactivity of a Terminal Magnesium Hydride Compound with a Carbatrane Motif, [TismPriBenz]MgH: A Multifunctional Catalyst for …
The tris [(1-isopropylbenzimidazol-2-yl) dimethylsilyl)] methyl ligand,[TismPriBenz], has been
employed to form the magnesium carbatrane compound,[TismPriBenz] MgH, which …
employed to form the magnesium carbatrane compound,[TismPriBenz] MgH, which …
[HTML][HTML] Synthesis and cytotoxicity evaluation of novel 1, 8-acridinedione derivatives bearing phthalimide moiety as potential antitumor agents
In this study, we aimed to develop hybrid antitumor compounds by synthesizing and
characterizing novel N-substituted acrididine-1, 8-dione derivatives, designed as hybrids of …
characterizing novel N-substituted acrididine-1, 8-dione derivatives, designed as hybrids of …
Regioselective synthesis of 1, 2-dihydropyridines by rhodium-catalyzed hydroboration of pyridines
K Oshima, T Ohmura, M Suginome - Journal of the American …, 2012 - ACS Publications
Pyridine undergoes addition of pinacolborane at 50° C in the presence of a rhodium
catalyst, giving N-boryl-1, 2-dihydropyridine in a high yield. The selective 1, 2-hydroboration …
catalyst, giving N-boryl-1, 2-dihydropyridine in a high yield. The selective 1, 2-hydroboration …