Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …

In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …

Vascular endothelial growth factor (VEGF) is a major driver of blood vessel formation.
However, the signal transduction pathways culminating in the biological consequences of …

Simple Summary Despite the continuous development of treatment technology,
glioblastoma remains a challenge for modern medicine. The standard of care remains a …

The development of carbon based hollow-structured nanospheres (HNSs) materials has
stimulated growing interest due to their controllable structure, high specific surface area …

High-grade gliomas (HGGs) are vascular tumors that represent attractive targets for
antiangiogenic therapies. In this Review, we present the rationale and clinical trial evidence …

Purpose Antivascular endothelial growth factor (anti-VEGF) therapy is a promising treatment
approach for patients with recurrent glioblastoma. This single-arm phase II study evaluated …

Glioblastoma is the most frequent and devastating primary malignant brain tumor in adults.
Surgery followed by standard radiotherapy with concomitant and adjuvant chemotherapy …

Background Despite optimum treatment with surgery, radiation therapy, and chemotherapy,
most patients with malignant glioma have a poor prognosis. Malignant gliomas are vascular …

Radiotherapy has been used for the treatment of cancer for over a century. Throughout this
period, the therapeutic benefit of radiotherapy has continuously progressed due to technical …