Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a
potential cancer therapeutic. However, the mechanisms underlying the initiation …

The cell contains various organelles that perform different functions using different biological
processes to form a complete organic architecture. Healthy cells and tumor cells often show …

Whole-genome duplication (WGD) is one of the most common genomic abnormalities in
cancers. WGD can provide a source of redundant genes to buffer the deleterious effect of …

Developing radiosensitizers based on the characteristics of the tumor microenvironment can
improve the effectiveness and overcome the bottleneck of cervical cancer radiotherapy …

Fluorouracil (5-FU)-based chemotherapy is the first-line treatment for colorectal cancer
(CRC) but is hampered by chemoresistance. Despite its impact on patient survival, the …

During its division the cell must ensure the equal distribution of its genetic material in the two
newly created cells, but it must also distribute organelles such as the Golgi apparatus, the …

Centrosome amplification (CA) is a hallmark of cancer that is strongly associated with highly
aggressive disease and worse clinical outcome. Clustering extra centrosomes is a major …

Simple Summary Precise chromosome segregation during mitosis is a vital event
orchestrated by formation of bipolar spindle poles. Supernumerary centrosomes, caused by …

Cancer-associated fibroblasts (CAFs) are abundant stromal cells in the tumor
microenvironment that promote cancer progression and relapse. However, the …

The nucleus undergoes dramatic structural and functional changes during cell division. With
the entry into mitosis, in human cells the nuclear envelope breaks down, chromosomes …