Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

Of wide interest for health is the relation existing between depression, a very common
psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult …

The capability of the mammalian brain to generate new neurons through the lifespan has
gained much attention for the promise of new therapeutic possibilities especially for the …

Selective serotonin reuptake inhibitors (SSRIs) represent the most common treatment for
major depression. However, their efficacy is variable and incomplete. In order to elucidate …

Depression like many diseases is pleiotropic but unlike cancer and Alzheimer's disease for
example, is still largely stigmatized and falls into the dark shadows of human illness. The …

We tested the effect of early-life stress (ELS)–24 h maternal deprivation (MD) at postnatal
day (PND) 3–on cognitive performance and hippocampal structure in 12–17-week-old …

Chronic stress can provoke depressive-like behaviors through activation of inflammation
and apoptosis, leading to a reduction of neurons. Antidepressant therapy may contribute to …

Although the literature reports a higher incidence of anxiety disorders in women, the majority
of basic research has focused on male rodents, thus resulting in a lack of knowledge on the …

Background Drugs prescribed for psychiatric disorders in adolescence should be studied
very extensively since they can affect developing and thus highly plastic brain differently …

Adult neurogenesis involves the generation of new neurons, particularly in the dentate gyrus
of the hippocampus. Decreased hippocampal neurogenesis has been implicated in both …