Lipogenesis inhibitors: therapeutic opportunities and challenges

B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Cellular host factors for SARS-CoV-2 infection

J Baggen, E Vanstreels, S Jansen, D Daelemans - Nature Microbiology, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

Y Zhou, Y Hou, J Shen, Y Huang, W Martin, F Cheng - Cell discovery, 2020 - nature.com
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

L Riva, S Yuan, X Yin, L Martin-Sancho, N Matsunaga… - Nature, 2020 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …

A metabolic handbook for the COVID-19 pandemic

JS Ayres - Nature metabolism, 2020 - nature.com
For infectious-disease outbreaks, clinical solutions typically focus on efficient pathogen
destruction. However, the COVID-19 pandemic provides a reminder that infectious diseases …

Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases

RM Meganck, RS Baric - Nature medicine, 2021 - nature.com
The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

S Yuan, X Yin, X Meng, JFW Chan, ZW Ye, L Riva… - Nature, 2021 - nature.com
The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a
coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 2003 …

Role of vitamins and minerals as immunity boosters in COVID-19

P Kumar, M Kumar, O Bedi, M Gupta, S Kumar… - …, 2021 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) known as coronavirus
disease (COVID-19), emerged in Wuhan, China, in December 2019. On March 11, 2020, it …

The role of lipid metabolism in COVID-19 virus infection and as a drug target

M Abu-Farha, TA Thanaraj, MG Qaddoumi… - International journal of …, 2020 - mdpi.com
The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million
people and resulted in the death of over one hundred thousand people at the time of writing …

Double-membrane vesicles as platforms for viral replication

G Wolff, CE Melia, EJ Snijder, M Bárcena - Trends in microbiology, 2020 - cell.com
Viruses, as obligate intracellular parasites, exploit cellular pathways and resources in a
variety of fascinating ways. A striking example of this is the remodelling of intracellular …