Lipogenesis inhibitors: therapeutic opportunities and challenges
B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
Cellular host factors for SARS-CoV-2 infection
Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …
and caused a global economic crisis. No effective antiviral drugs are currently available to …
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …
has triggered an ongoing global pandemic of the severe pneumonia-like disease …
A metabolic handbook for the COVID-19 pandemic
JS Ayres - Nature metabolism, 2020 - nature.com
For infectious-disease outbreaks, clinical solutions typically focus on efficient pathogen
destruction. However, the COVID-19 pandemic provides a reminder that infectious diseases …
destruction. However, the COVID-19 pandemic provides a reminder that infectious diseases …
Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases
RM Meganck, RS Baric - Nature medicine, 2021 - nature.com
The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a
coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 2003 …
coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 2003 …
Role of vitamins and minerals as immunity boosters in COVID-19
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) known as coronavirus
disease (COVID-19), emerged in Wuhan, China, in December 2019. On March 11, 2020, it …
disease (COVID-19), emerged in Wuhan, China, in December 2019. On March 11, 2020, it …
The role of lipid metabolism in COVID-19 virus infection and as a drug target
M Abu-Farha, TA Thanaraj, MG Qaddoumi… - International journal of …, 2020 - mdpi.com
The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million
people and resulted in the death of over one hundred thousand people at the time of writing …
people and resulted in the death of over one hundred thousand people at the time of writing …
Double-membrane vesicles as platforms for viral replication
G Wolff, CE Melia, EJ Snijder, M Bárcena - Trends in microbiology, 2020 - cell.com
Viruses, as obligate intracellular parasites, exploit cellular pathways and resources in a
variety of fascinating ways. A striking example of this is the remodelling of intracellular …
variety of fascinating ways. A striking example of this is the remodelling of intracellular …