Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

Mechanical damage is one of the predisposing factors of inflammation, and it runs through
the entire inflammatory pathological process. Repeated or persistent damaging mechanical …

Microglia are emerging as key drivers of neurological diseases. However, we lack a
systematic understanding of the underlying mechanisms. Here, we present a screening …

Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …

Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Microglia-mediated neuroinflammation and mitochondrial dysfunction play critical role in the
pathogenic process of Parkinson's disease (PD). Mitophagy plays central role in …

Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive
clinical challenge, inspiring intensified interest in therapeutic approaches to explore superior …

Increasing evidences suggest that inflammation plays a key role in the pathogenesis of
stroke, a devastating disease second only to cardiac ischemia as a cause of death …

Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Background Microglial activation-mediated neuroinflammation plays an important role in the
progression of neurodegenerative diseases. Inflammatory activation of microglial cells is …