Peptidyl toxins are used extensively to determine the pharmacology of ion channels. Four
families of peptides have been purified from scorpion venom. In this article, the classification …

Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety
of cells and tissues following channel activation. It is now recognized that BK channels …

Molecular toxinology research was initially driven by an interest in the small subset of animal
toxins that are lethal to humans. However, the realization that many venomous creatures …

The primary function of the presynaptic nerve terminal is to release transmitter quanta and
thus activate the postsynaptic target cell. In almost every step leading to the release of …

Six mutants of SLO-1, a large-conductance, Ca 2+-activated K+ channel of C. elegans, were
obtained in a genetic screen for regulators of neurotransmitter release. Mutants were …

Large-conductance calcium-activated potassium (BK) channels are colocalized with calcium
channels at sites of exocytosis at the presynaptic terminals throughout the nervous system. It …

Abstract Large conductance, Ca 2+-activated potassium (BK) channels play important roles
in the regulation of neuronal excitability and the control of smooth muscle contractions. BK …

Scorpion envenomation is a life-threatening toxicological emergency and considered as a
major public health problem, especially in endemic regions (India, Africa, Latin America); it is …

Indian Red Scorpion (Mesobuthus tamulus) stings are a neglected public health problem in
tropical and sub-tropical countries, including India. The drawbacks of conventional therapies …

Four peptidyl inhibitors of the small‐conductance Ca2+‐activated K+ channels (SKCa) have
been isolated from the venom of the Chinese scorpion Buthus martensi. These peptides …