The two major interfaces separating brain and blood have different primary roles. The
choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid …

The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

Speciation leads to adaptive changes in organ cellular physiology and creates challenges
for studying rare cell-type functions that diverge between humans and mice. Rare cystic …

Prior RNA sequencing (RNA-seq) studies have identified complete transcriptomes for most
renal epithelial cell types. The exceptions are the cell types that make up the renal collecting …

Molecular Physiology of Water Balance | New England Journal of Medicine Skip to main content
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Abstract Fibroblast growth factor‐23 (FGF 23) is a bone‐derived hormone regulating renal
phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show …

The recently discovered epithelial sodium channel (ENaC)/degenerin (DEG) gene family
encodes sodium channels involved in various cell functions in metazoans. Subfamilies …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in
defective epithelial cAMP-dependent Cl− secretion and increased airway Na+ absorption …

Essential hypertension is a common disease, yet its pathogenesis is not well understood.
Altered control of sodium excretion in the kidney may be a key causative feature, but this has …