Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an
extensive and complex metabolism along several pathways, resulting in many bioactive …

Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

Overweight and obesity are associated with several cardiometabolic risk factors, including
insulin resistance, type 2 diabetes, low-grade inflammation and liver diseases. The gut …

Background Although microbioa‐based therapies have shown putative effects on the
treatment of non‐alcoholic fatty liver disease (NAFLD), it is not clear how microbiota‐derived …

Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …

The gastrointestinal tract hosts the largest ecosystem of microorganisms in the body. The
metabolism of ingested nutrients by gut bacteria produces novel chemical mediators that …

Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial
when it concerns fat mass, but loss of fat free mass–especially muscle might be detrimental …

Indole and its derivatives are widespread across different life forms, functioning as signalling
molecules in prokaryotes and with more diverse roles in eukaryotes. A majority of indoles …

The increasing prevalence of metabolic syndrome has become a serious public health
problem. Certain bacteria-derived metabolites play a key role in maintaining human health …