The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to
study using current in vitro models such as primary human hepatocyte (PHH) monolayer …

The inadequacy of animal models in correctly predicting drug and biothreat agent toxicity in
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …

Modeling clinically relevant tissue responses using cell models poses a significant
challenge for drug development, in particular for drug induced liver injury (DILI). This is …

Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …

Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional
cell cultures possessing certain key characteristics of their organ counterparts, and they can …

Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with
their host. Models of human cancer in vitro, used in cancer biology and drug discovery, are …

The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …

Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …