Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

Cellular senescence is now considered an important driving mechanism for chronic lung
diseases, particularly chronic obstructive pulmonary disease (COPD) and idiopathic …

Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general
lack of concordance in the stem cell field with many distinct cell subtypes continually …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …

The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

The presence of DNA in the cytosol is usually a sign of microbial infections, which alerts the
host innate immune system to mount a defense response. Cyclic GMP-AMP synthase …

Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,
increasing vascular permeability, promoting activation of the coagulation cascade, tissue …

Aging causes a progressive decline in the structure and function of organs. With advancing
age, an accumulation of senescent endothelial cells (ECs) contributes to the risk of …

Aging is one of the most important risk factors for most chronic diseases. The worldwide
increase in life expectancy has been accompanied by an increase in the prevalence of age …