Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

NMR spectroscopy for metabolomics research

AH Emwas, R Roy, RT McKay, L Tenori, E Saccenti… - Metabolites, 2019 - mdpi.com
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …

Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

F Cappellesso, MP Orban, N Shirgaonkar, E Berardi… - Nature Cancer, 2022 - nature.com
Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …

Metabolic pathway analysis using stable isotopes in patients with cancer

CR Bartman, B Faubert, JD Rabinowitz… - Nature Reviews …, 2023 - nature.com
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

Glutamine and cancer: cell biology, physiology, and clinical opportunities

CT Hensley, AT Wasti… - The Journal of clinical …, 2013 - Am Soc Clin Investig
Glutamine is an abundant and versatile nutrient that participates in energy formation, redox
homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics …

Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo

HM De Feyter, KL Behar, ZA Corbin, RK Fulbright… - Science …, 2018 - science.org
Currently, the only widely available metabolic imaging technique in the clinic is positron
emission tomography (PET) detection of the radioactive glucose analog 2-18F-fluoro-2 …

A molecular imaging primer: modalities, imaging agents, and applications

ML James, SS Gambhir - Physiological reviews, 2012 - journals.physiology.org
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

[HTML][HTML] Cellular metabolism and disease: what do metabolic outliers teach us?

RJ DeBerardinis, CB Thompson - Cell, 2012 - cell.com
An understanding of metabolic pathways based solely on biochemistry textbooks would
underestimate the pervasive role of metabolism in essentially every aspect of biology. It is …

Parahydrogen‐based hyperpolarization for biomedicine

JB Hövener, AN Pravdivtsev, B Kidd… - Angewandte Chemie …, 2018 - Wiley Online Library
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …

[HTML][HTML] Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies

LM Phan, SCJ Yeung, MH Lee - Cancer biology & medicine, 2014 - ncbi.nlm.nih.gov
Cancer cells are well documented to rewire their metabolism and energy production
networks to support and enable rapid proliferation, continuous growth, survival in harsh …