Abstract Dopamine D2 autoreceptors (D 2 ARs), located in somatodendritic and axon
terminal compartments of dopamine (DA) neurons, function to provide a negative feedback …

Dopaminergic signaling in the nucleus accumbens shell (NAc) regulates neuronal activity
relevant to reward-related learning, including cocaine-associated behaviors. Although …

Diverse classes of voltage-gated potassium channels (Kv) are integral to the variety of
electrical activity patterns that distinguish different classes of neurons in the brain. A feature …

Opioid withdrawal generates extremely unpleasant physical symptoms and negative
affective states. A rapid relief of opioid withdrawal-induced anxiety has obvious clinical …

Background Cannabis exposure during adolescence is associated with emotional and
motivational alterations that may entail an enhanced risk of developing psychiatric disorders …

Dopamine signaling is constrained to discrete tracts yet has brain-wide effects on neural
activity. The nature of this relationship between local dopamine signaling and brain-wide …

Background The identification of novel toxins from overlooked and taxonomically
exceptional species bears potential for various pharmacological applications. The remipede …

We identified a new human voltage-gated potassium channel blocker, NnK-1, in the jellyfish
Nemopilema nomurai based on its genomic information. The gene sequence encoding NnK …

Being motivated means exerting effort toward a goal. The 'law of least work'emphasizes a
preference for exerting relatively less effort. The law crosses boundaries among species and …

Purpose This study aimed to investigate the effect of small-conductance calcium-activated
potassium channels (SK channels) on the dopaminergic (DA) neuron pathways in the …