Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …

Like most solid tumours, the microenvironment of epithelial-derived gastric adenocarcinoma
(GAC) consists of a variety of stromal cell types, including fibroblasts, and neuronal …

Immune checkpoint therapy (ICT) provides substantial clinical benefits to cancer patients,
but a large proportion of cancers do not respond to ICT. To date, the genomic underpinnings …

Background Deciphering intra‐and inter‐tumoural heterogeneity is essential for
understanding the biology of gastric cancer (GC) and its metastasis and identifying effective …

Single-cell sequencing (SCS) is an emerging high-throughput technology that can be used
to study the genomics, transcriptomics, and epigenetics at a single cell level. SCS is widely …

Peritoneal metastasis is the leading cause of death for gastrointestinal cancers. The native
and therapy-induced ascites ecosystems are not fully understood. Here, we characterize …

Intratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of
ITH remain poorly understood. We performed single-cell transcriptome profiling of peritoneal …

Gastric cancer is an active topic of clinical and basic research due to high morbidity and
mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric …

One of the most unexpected discoveries in molecular oncology, in the last decades, was the
identification of a new layer of protein coding gene regulation by transcripts that do not …

Peritoneal metastasis, a hallmark of incurable advanced gastric cancer (GC), presently has
no curative therapy and its molecular features have not been examined extensively. Here …