Recombinant protein vaccines, a proven approach against coronavirus pandemics

J Pollet, WH Chen, U Strych - Advanced drug delivery reviews, 2021 - Elsevier
With the COVID-19 pandemic now ongoing for close to a year, people all over the world are
still waiting for a vaccine to become available. The initial focus of accelerated global …

[HTML][HTML] Comparative safety of vaccine adjuvants: a summary of current evidence and future needs

N Petrovsky - Drug safety, 2015 - Springer
Use of highly pure antigens to improve vaccine safety has led to reduced vaccine
immunogenicity and efficacy. This has led to the need to use adjuvants to improve vaccine …

Developments in vaccine adjuvants

FZ Firdaus, M Skwarczynski, I Toth - Vaccine Design: Methods and …, 2022 - Springer
Vaccines, including subunit, recombinant, and conjugate vaccines, require the use of an
immunostimulator/adjuvant for maximum efficacy. Adjuvants not only enhance the strength …

Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung …

Y Honda-Okubo, D Barnard, CH Ong, BH Peng… - Journal of …, 2015 - Am Soc Microbiol
Although the severe acute respiratory syndrome-associated coronavirus (SARS-CoV)
epidemic was controlled by nonvaccine measures, coronaviruses remain a major threat to …

[HTML][HTML] Flaviviruses in Europe: complex circulation patterns and their consequences for the diagnosis and control of West Nile disease

C Beck, MA Jimenez-Clavero, A Leblond… - International journal of …, 2013 - mdpi.com
In Europe, many flaviviruses are endemic (West Nile, Usutu, tick-borne encephalitis viruses)
or occasionally imported (dengue, yellow fever viruses). Due to the temporal and …

Immunogenicity and safety of SpikoGen®, an adjuvanted recombinant SARS‐CoV‐2 spike protein vaccine as a homologous and heterologous booster vaccination: a …

P Tabarsi, N Anjidani, R Shahpari… - …, 2022 - Wiley Online Library
SpikoGen® is a subunit recombinant spike protein vaccine combined with Advax‐CpG55.
2™ adjuvant. This COVID‐19 vaccine was shown to be safe, immunogenic and efficacious …

[HTML][HTML] Usutu virus: an emerging flavivirus in Europe

U Ashraf, J Ye, X Ruan, S Wan, B Zhu, S Cao - Viruses, 2015 - mdpi.com
Usutu virus (USUV) is an African mosquito-borne flavivirus belonging to the Japanese
encephalitis virus serocomplex. USUV is closely related to Murray Valley encephalitis virus …

Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety

N Petrovsky, PD Cooper - Vaccine, 2015 - Elsevier
There is an ongoing need for new adjuvants to facilitate development of vaccines against
HIV, tuberculosis, malaria and cancer, amongst many others. Unfortunately, the most potent …

[HTML][HTML] Prefusion RSV F immunization elicits Th2-mediated lung pathology in mice when formulated with a Th2 (but not a Th1/Th2-balanced) adjuvant despite …

KM Eichinger, JL Kosanovich, SV Gidwani… - Frontiers in …, 2020 - frontiersin.org
Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract
infections in children worldwide. Development of a vaccine has been hindered by the risk of …

[HTML][HTML] The Japanese encephalitis antigenic complex viruses: from structure to immunity

B Khare, RJ Kuhn - Viruses, 2022 - mdpi.com
In the last three decades, several flaviviruses of concern that belong to different antigenic
groups have expanded geographically. This has resulted in the presence of often more than …