Due to recent discovery efforts, over 100 immune systems encoded by bacteria that
antagonize bacteriophage (phage) replication have been uncovered. These systems …

Bacteria have diverse defenses against phages. In response, jumbo phages evade multiple
DNA-targeting defenses by protecting their DNA inside a nucleus-like structure. We …

Nucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating
intricate structures for viral replication. Research on this newly appreciated family of phages …

Host-pathogen interactions are pivotal in regulating establishment, progression, and
outcome of an infection. While affinity-purification mass spectrometry has become …

Viral genomes are most vulnerable to cellular defenses at the start of the infection. A family
of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles …

The giant myovirus phiKZ is characterised by an Inner Body (IB) structure within its capsid,
crucial for orderly DNA packaging. The IB is composed of six phiKZ-specific proteins …

Phage therapeutics offer a potentially powerful approach for combating multidrug-resistant
bacterial infections. However, to be effective, phage therapy must overcome existing and …

Viruses have been evolving host-modifying factors for billions of years. Genomes of bacterial
and archaeal viruses are replete with fast-evolving, uncharacterized accessory genes (AGs) …

As nucleus-forming phages become better characterized, understanding their unifying
similarities and unique differences will help us understand how they occupy varied niches …

A fundamental strategy of eukaryotic anti-viral innate immunity involves the cGAS enzyme,
which synthesizes 2', 3'-cGAMP and activates a STING effector to limit viral replication …