Defining the expanding mechanisms of phage-mediated activation of bacterial immunity
E Huiting, J Bondy-Denomy - Current opinion in microbiology, 2023 - Elsevier
Due to recent discovery efforts, over 100 immune systems encoded by bacteria that
antagonize bacteriophage (phage) replication have been uncovered. These systems …
antagonize bacteriophage (phage) replication have been uncovered. These systems …
Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection
Bacteria have diverse defenses against phages. In response, jumbo phages evade multiple
DNA-targeting defenses by protecting their DNA inside a nucleus-like structure. We …
DNA-targeting defenses by protecting their DNA inside a nucleus-like structure. We …
The intricate organizational strategy of nucleus-forming phages
A Prichard, J Pogliano - Current Opinion in Microbiology, 2024 - Elsevier
Nucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating
intricate structures for viral replication. Research on this newly appreciated family of phages …
intricate structures for viral replication. Research on this newly appreciated family of phages …
Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping
A Fossati, D Mozumdar, C Kokontis… - Nature …, 2023 - nature.com
Host-pathogen interactions are pivotal in regulating establishment, progression, and
outcome of an infection. While affinity-purification mass spectrometry has become …
outcome of an infection. While affinity-purification mass spectrometry has become …
Characterization of a lipid-based jumbo phage compartment as a hub for early phage infection
Viral genomes are most vulnerable to cellular defenses at the start of the infection. A family
of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles …
of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles …
Assembly of phiKZ bacteriophage Inner Body during infection
A Nichiporenko, D Antonova, I Kurdyumova… - Biochemical and …, 2024 - Elsevier
The giant myovirus phiKZ is characterised by an Inner Body (IB) structure within its capsid,
crucial for orderly DNA packaging. The IB is composed of six phiKZ-specific proteins …
crucial for orderly DNA packaging. The IB is composed of six phiKZ-specific proteins …
Correlation of Pseudomonas aeruginosa Phage Resistance with the Numbers and Types of Antiphage Systems
KA Burke, CD Urick, N Mzhavia, MP Nikolich… - International Journal of …, 2024 - mdpi.com
Phage therapeutics offer a potentially powerful approach for combating multidrug-resistant
bacterial infections. However, to be effective, phage therapy must overcome existing and …
bacterial infections. However, to be effective, phage therapy must overcome existing and …
Activation of programmed cell death and counter-defense functions of phage accessory genes
Viruses have been evolving host-modifying factors for billions of years. Genomes of bacterial
and archaeal viruses are replete with fast-evolving, uncharacterized accessory genes (AGs) …
and archaeal viruses are replete with fast-evolving, uncharacterized accessory genes (AGs) …
[HTML][HTML] Asesino: a nucleus-forming phage that lacks PhuZ
As nucleus-forming phages become better characterized, understanding their unifying
similarities and unique differences will help us understand how they occupy varied niches …
similarities and unique differences will help us understand how they occupy varied niches …
Understanding the mechanism of bacterial cGAS immunity and its co-evolution with phage
E Huiting - 2024 - escholarship.org
A fundamental strategy of eukaryotic anti-viral innate immunity involves the cGAS enzyme,
which synthesizes 2', 3'-cGAMP and activates a STING effector to limit viral replication …
which synthesizes 2', 3'-cGAMP and activates a STING effector to limit viral replication …