As the main biomarkers of most diseases, enzymes play fundamental but extremely critical
roles in biosystems. High-resolution studies of enzymes using activatable in situ …

Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective
edge tools for the investigation of cell biology and disease diagnosis because of their …

Calix [n] arenes (n= 4, 5, 6, 8) are “chalicelike” phenol-based macrocycles that are among
the most fascinating and highly studied scaffolds in supramolecular chemistry. This stems …

Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Hypoxia as one characteristic hallmark of solid tumors has been demonstrated to be
involved in cancer metastasis and progression, induce severe resistance to oxygen …

Tumor‐specific, hypoxia‐activated prodrugs have been developed to alleviate the side
effects of chemotherapy drugs. However, the release efficiency of hypoxia‐activated …

Poor tumor penetration is a major challenge for the use of nanoparticles in anticancer
therapy. Moreover, the inability to reach hypoxic tumor cells that are distant from blood …

Hypoxia, the typical and conspicuous characteristic of most solid tumors, worsens the tumor
invasiveness and metastasis. Here, we engineered a sequential ultrasound (US)/hypoxia …

Photodynamic therapy (PDT), a noninvasive cancer therapeutic method triggered by light,
would lead to severe tumor hypoxia after treatment. Utilizing a hypoxia-activated prodrug …

Advances in bioinformatics, genomics, proteomics, and metabolomics have facilitated the
development of novel anticancer agents that have decreased side effects and increased …