Calcium ion (Ca 2+) is a ubiquitous and versatile signaling molecule controlling a wide
variety of cellular processes, such as proliferation, cell death, migration, and immune …

Esophageal cancer (EC) is one of the most common cancers with high morbidity and
mortality rates. EC includes two histological subtypes, namely esophageal squamous cell …

The old Greek aphorism 'Panta Rhei'('everything flows') is true for all living things in general.
As a dynamic process, calcium signaling plays fundamental roles in cellular activities under …

Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling
(ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of …

Calcium release-activated calcium (CRAC) channels have been the target of drug discovery
for many years. The identification of STIM and Orai proteins as key components of CRAC …

In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium
Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways …

Calcium (Ca2+) release–activated Ca2+ (CRAC) channels are a major route for Ca2+ entry
in eukaryotic cells. These channels are store operated, opening when the endoplasmic …

Highlights•Drug resistance of cancer cells, which results in treatment failure, is a major
concern in medical oncology.•Ca 2+ plays an important role in acquired drug resistance by …

Store-operated Ca2+ entry (SOCE) is the major pathway of Ca2+ entry in mammalian cells,
and regulates a variety of cellular functions including proliferation, motility, apoptosis, and …

Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …