The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early
brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have indicated …

Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1–
7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of …

Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1
(ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in …

Abstract Purpose of Review Although an independent brain renin-angiotensin system is
often assumed to exist, evidence for this concept is weak. Most importantly, renin is lacking …

All the components of the classic renin–angiotensin system (RAS) have been identified in
the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor …

Previously, we revealed that brain Ang-(1-7) deficiency was involved in the pathogenesis of
sporadic Alzheimer's disease (AD). We speculated that restoration of brain Ang-(1-7) levels …

Recent studies showed that angiotensin-(1-7) has cerebroprotective actions in stroke. In the
present study, we aim to test whether tissue overexpression of Angiotensin-(1-7), mainly in …