The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Muscular dystrophies are a heterogeneous group of inherited disorders that share similar
clinical features and dystrophic changes on muscle biopsy. An improved understanding of …

Ryanodine receptors (RyRs) and inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …

Calcium (Ca2+) release from intracellular stores controls numerous cellular processes,
including cardiac and skeletal muscle contraction, synaptic transmission and metabolism …

Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+) release channels
required for the function of many organs including heart and skeletal muscle, synaptic …

Regulation of intracellular calcium (Ca 2+) is critical in all cell types. The ryanodine receptor
(RyR), an intracellular Ca 2+ release channel located on the sarco/endoplasmic reticulum …

Muscular dystrophies are a group of diseases characterised by the primary wasting of
skeletal muscle, which compromises patient mobility and in the most severe cases originate …

Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …

Muscular dystrophy (MD) refers to a clinically and genetically heterogeneous group of
degenerative muscle disorders characterized by progressive muscle wasting and often …

Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disease which to date
is incurable. The major cause of death is dilated cardiomyopathy however, its pathogenesis …