Mitochondrial oxidative stress in aging and healthspan
The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …
Muscular dystrophies
E Mercuri, F Muntoni - The Lancet, 2013 - thelancet.com
Muscular dystrophies are a heterogeneous group of inherited disorders that share similar
clinical features and dystrophic changes on muscle biopsy. An improved understanding of …
clinical features and dystrophic changes on muscle biopsy. An improved understanding of …
Intracellular calcium release channels: an update
G Santulli, R Nakashima, Q Yuan… - The Journal of …, 2017 - Wiley Online Library
Ryanodine receptors (RyRs) and inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …
Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging
G Santulli, AR Marks - Current molecular pharmacology, 2015 - ingentaconnect.com
Calcium (Ca2+) release from intracellular stores controls numerous cellular processes,
including cardiac and skeletal muscle contraction, synaptic transmission and metabolism …
including cardiac and skeletal muscle contraction, synaptic transmission and metabolism …
Ryanodine receptor structure and function in health and disease
Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+) release channels
required for the function of many organs including heart and skeletal muscle, synaptic …
required for the function of many organs including heart and skeletal muscle, synaptic …
[HTML][HTML] Ryanodine receptor dysfunction in human disorders
A Kushnir, B Wajsberg, AR Marks - … et Biophysica Acta (BBA)-Molecular Cell …, 2018 - Elsevier
Regulation of intracellular calcium (Ca 2+) is critical in all cell types. The ryanodine receptor
(RyR), an intracellular Ca 2+ release channel located on the sarco/endoplasmic reticulum …
(RyR), an intracellular Ca 2+ release channel located on the sarco/endoplasmic reticulum …
Dysregulation of calcium homeostasis in muscular dystrophies
A Vallejo-Illarramendi, I Toral-Ojeda… - Expert reviews in …, 2014 - cambridge.org
Muscular dystrophies are a group of diseases characterised by the primary wasting of
skeletal muscle, which compromises patient mobility and in the most severe cases originate …
skeletal muscle, which compromises patient mobility and in the most severe cases originate …
Altered Ca2+ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease
A Michelucci, C Liang, F Protasi, RT Dirksen - Metabolites, 2021 - mdpi.com
Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …
Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy
AR Burr, JD Molkentin - Cell Death & Differentiation, 2015 - nature.com
Muscular dystrophy (MD) refers to a clinically and genetically heterogeneous group of
degenerative muscle disorders characterized by progressive muscle wasting and often …
degenerative muscle disorders characterized by progressive muscle wasting and often …
Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression
V Marini, F Marino, F Aliberti, N Giarratana… - Frontiers in Cell and …, 2022 - frontiersin.org
Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disease which to date
is incurable. The major cause of death is dilated cardiomyopathy however, its pathogenesis …
is incurable. The major cause of death is dilated cardiomyopathy however, its pathogenesis …