Acetylcholine (ACh) can effect vasodilation by several mechanisms, including activation of
endothelial nitric oxide (NO) synthase and prostaglandin (PG) production. In human skin …

Previous work indicates that sympathetic nerves participate in the vascular responses to
direct cooling of the skin in humans. We evaluated this hypothesis further in a four-part …

Nitric oxide (NO) participates in locally mediated vasodilation induced by increased local
skin temperature (Tloc) and in sympathetically mediated vasodilation during whole body …

Presynaptic blockade of cutaneous vasoconstrictor nerves (VCN) abolishes the axon reflex
(AR) during slow local heating (SLH) and reduces the vasodilator response. In a two-part …

Microdialysis enables in-depth mechanistic study of the cutaneous circulation in humans.
However, whether the insertion or presence of the microdialysis fiber (MDF) affects the skin …

Slow local skin heating (LH) causes vasodilator responses, some of which are dependent
on sympathetic nerve function. It is not known, however, how the rate of LH affects either the …

Low flow postural tachycardia syndrome (POTS), is associated with reduced nitric oxide
(NO) activity assumed to be of endothelial origin. We tested the hypothesis that cutaneous …

This study examined whether nitric oxide (NO) is involved in the cutaneous response to
reactive hyperemia (RH) in the human forearm. We enrolled seven healthy volunteers. NO …

We tested the hypothesis that cyclooxygenases (COXs) or COX products inhibit nitric oxide
(NO) synthesis and thereby mask potential effects of NO on reactive hyperemia in the …

We dissected the relative contribution of arteriovenous hemodynamics, the venoarteriolar
response (VAR), and the myogenic reflex toward a decrease in local blood flow induced by …