Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics
Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …
DNA methylation cancer biomarkers: translation to the clinic
Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …
These changes are characterized by a globally hypomethylated genome with focal …
[HTML][HTML] Non-invasive early detection of cancer four years before conventional diagnosis using a blood test
X Chen, J Gole, A Gore, Q He, M Lu, J Min… - Nature …, 2020 - nature.com
Early detection has the potential to reduce cancer mortality, but an effective screening test
must demonstrate asymptomatic cancer detection years before conventional diagnosis in a …
must demonstrate asymptomatic cancer detection years before conventional diagnosis in a …
Liquid biopsy of methylation biomarkers in cell-free DNA
H Luo, W Wei, Z Ye, J Zheng, R Xu - Trends in molecular medicine, 2021 - cell.com
Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …
Next-generation sequencing in liquid biopsy: cancer screening and early detection
M Chen, H Zhao - Human genomics, 2019 - Springer
In recent years, the rapid development of next-generation sequencing (NGS) technologies
has led to a significant reduction in sequencing cost with improved accuracy. In the area of …
has led to a significant reduction in sequencing cost with improved accuracy. In the area of …
Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
A decade of transcription factor-mediated reprogramming to pluripotency
K Takahashi, S Yamanaka - Nature reviews Molecular cell biology, 2016 - nature.com
The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
DNA methylation markers for diagnosis and prognosis of common cancers
The ability to identify a specific cancer using minimally invasive biopsy holds great promise
for improving the diagnosis, treatment selection, and prediction of prognosis in cancer …
for improving the diagnosis, treatment selection, and prediction of prognosis in cancer …
Large-scale de novo DNA synthesis: technologies and applications
For over 60 years, the synthetic production of new DNA sequences has helped researchers
understand and engineer biology. Here we summarize methods and caveats for the de novo …
understand and engineer biology. Here we summarize methods and caveats for the de novo …