The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …

The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell
adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis …

The epithelial-to-mesenchymal transition (EMT) is frequently co-opted by cancer cells to
enhance migratory and invasive cell traits. It is a key contributor to heterogeneity …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …