Alzheimer's disease (AD) is one of the most frequent causes of death and disability
worldwide and has a significant clinical and socioeconomic impact. In the search for novel …

Alzheimer's disease (AD) is the most common cause of dementia in elderly people. Because
of the lack of effective treatments for this illness, research focused on identifying compounds …

Drugs acting through 5-hydroxytryptamine (serotonin or 5-HT) systems modulate memory
and its alterations, although the mechanisms involved are poorly understood. 5-HT drugs …

Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor
6 (5-HT 6) improve memory and reverse amnesia, although the mechanisms involved are …

The 5-HT6 receptor (5-HT6R) has been in the spotlight for several years regarding CNS-
related diseases. We set out to discover novel, neutral 5-HT6R antagonists to improve off …

Agonists and antagonists of the 5-hydroxytryptamine (serotonin) receptor6 (5-HT6) or
receptor7 (5-HT7) might improve memory and/or reverse amnesia, although the …

The serotonin 5-HT6 receptor (5-HT6R) is amongst the recently discovered serotonergic
receptors with almost exclusive localization in the brain. Hence, this receptor is fast …

Certainly, beyond the implication of cholinergic system in memory and therapeutic
applications, the muscarinic antagonist scopolamine had been a remarkable amnesic agent …

4-(Piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives were designed and synthesized
as 5-HT6 receptor (5-HT6R) ligands. The lead compound 6a, from this series shows potent …

The discovery of non-basic N′-(arylsulfonyl) pyrazoline-1-carboxamidines as 5-HT 6
antagonists with unique structural features was recently disclosed. Here we describe how …