Quinoline, a privileged scaffold in medicinal chemistry, has always been associated with a
multitude of biological activities. Especially in antimalarial and anticancer research …

Background Acemannan is a bioactive polysaccharides promoting tissue repair. However,
the roles of acemannan in skin wound healing and the underlying molecular mechanisms …

Abstract Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes
of brain inflammation, injury, and neurodegeneration. Thrombin has been known as a …

Epithelial–mesenchymal transition (EMT) is a crucial step in tumor progression and has an
important role during cancer invasion and metastasis. Although fucosyltransferase IV (FUT4) …

Gene expression profiling of in vitro drug perturbations is useful for many biomedical
discovery applications including drug repurposing and elucidation of drug mechanisms …

Objective: To determine the effect and mechanism of the long non-coding RNA (lncRNA)
ncRuPAR (non-protein coding RNA, upstream of coagulation factor II thrombin receptor …

In the present study, novel 2-cyclopropyl-3-ethynyl-4-(4-fluorophenyl) quinolines (4a-l) were
recognized and evaluated as G-Protein Coupled Receptor (GPCR) ligands through …

Proliferative vitreoretinopathy is caused by the contraction of fibrotic membranes on the
epiretinal surface of the neurosensory retina, resulting in a traction retinal detachment and …

Thrombin stimulates platelets via a dual receptor system of protease-activated receptors
(PARs): PAR1 and PAR4. PAR1 activation induces a rapid and transient signal associated …

Epithelial–mesenchymal transition (EMT), proliferation and migration of RPE cells
characterize the development of proliferative vitreoretinopathy (PVR) and other fibro …