Covering: 1900 to 2011 The study of biologically active natural products has resulted in
seminal contributions to our understanding of living systems. In the case of electrophilic …

Recently advances in understanding the molecular basis of Alzheimer's disease have led to
the consideration of the relationship between cholinergic inhibitors and amyloid deposition …

Quinazolinones, which represent an important part of nitrogen‐containing six‐membered
heterocyclic compounds, are frequently used in drug design due to their wide biological …

A series of thizaolidin-4-one derivatives (3a-o) was synthesized with excellent yield (94–
97%) and the structures of the compounds were characterized with Fourier-transform …

The peripheral anionic site on acetylcholinesterase (AChE), located at the active center
gorge entry, encompasses overlapping binding sites for allosteric activators and inhibitors; …

Rivastigmine, a carbamate inhibitor of acetylcholinesterase, is already in use for treatment of
Alzheimer's disease under the trade name of Exelon. Rivastigmine carbamylates Torpedo …

A new series of donepezil–tacrine hybrid related derivatives have been synthesised as dual
acetylcholinesterase inhibitors that could bind simultaneously to the peripheral and catalytic …

The 3D structure of a complex of the anti‐Alzheimer drug galanthamine with Torpedo
californica acetylcholinesterase is reported. Galanthamine, a tertiary alkaloid extracted from …

Abstract Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that plays
important roles in narcotic metabolism, clinical prodrug activation, and the processing of fatty …

A 10-ns molecular dynamics simulation of mouse acetylcholinesterase was analyzed, with
special attention paid to the fluctuation in the width of the gorge and opening events of the …